Recombination-restarted replication makes inverted chromosome fusions at inverted repeats
نویسندگان
چکیده
منابع مشابه
Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae
Genome instability is linked to cancer and many hereditary diseases. Chromosomal aberrations are often associated with repeats that can adopt DNA secondary structures. Studying the mechanism of genome instability caused by unstable motifs will therefore contribute to our understanding of the origin of human pathology. In this study, we investigate the mechanism underlying inverted repeated asso...
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Replication, DNA organization, and mismatch repair (MMR) can influence recombination. We examined the effects of altered replication due to a mutation in the polymerase delta gene, long inverted repeats (LIRs) in motifs similar to those in higher eukaryotes, and MMR on intrachromosomal recombination between highly diverged (28%) truncated genes in Saccharomyces cerevisiae. A combination of alte...
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Certain DNA sequence motifs and structures can promote genomic instability. We have explored instability induced in mouse cells by long inverted repeats (LIRs). A cassette was constructed containing a herpes simplex virus thymidine kinase (tk) gene into which was inserted an LIR composed of two inverted copies of a 1.1-kb yeast URA3 gene sequence separated by a 200-bp spacer sequence. The tk ge...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature11676